Description

Other names: 5-HT-DOTA, 1-(5-Hydroxyindole-3-ethylacetamide)-4,7,10-triacetic acid-1,4,7,10-tetraazacyclododecane; DOTA-conjugate with serotonine.

This product is a ligand for the preparation of the imaging Gd-complex. It can be used as an activatable paramagnetic imaging agent to directly image myeloperoxydase (MPO). Secrecretion of MPO by activated macrophages and neutrophils in humans found to be in correlation with plaque rupture in atherosclerotic disease, that is the major cause of morbidity.

Ref.:

1) MRI Contrast Agents: From Molecules to Particles.

S. Laurent, C. Henoumont, D. Stanicki, S. Boutry, E. Lipani, S. Belaid, R.N. Muller, L.V. Elst, ISSN 2191-530X, 2017.

DOI: 10.1007/978.981.10.2529.7

2) High-resolution Imaging of Myeloperoxidase Activity Sensors in Human Cerebrovascular Disease.

Y.Z. Wadghiri, D.M. Hoang, A. Leporati, M.J. Gounis, A. Rodríguez-Rodríguez, M.L. Mazzanti, J.P. Weaver, A.K. Wakhloo, P. Caravan, A.A. Bogdanov Jr, Sci Rep 2018, 8, 7687. Open Access

DOI: 10.1038/s41598-018-25804-y