Description

Other names: MMA-DOTA. 1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-maleimidoethylacetamide.

This product can be used for the preparation of metal complexes for MRI applications. Specific reactivity toward thiol-groups allows labeling of peptides and other biomolecules under mild conditions.

Ref.:

1) Evaluation of Maleimide Derivative of DOTA for Site-Specific Labeling of Recombinant Affibody Molecules.

S. Ahlgren, A. Orlova, D. Rosik, M. Sandström, Bioconjugate Chem. 2008, 19, 235-243.

DOI: 10.1021/bc700307y

2) Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA.

M.-A. Elvina Xavier, S. Liu, S.H. Leppla, B. Cornelissen, Nucl. Med. Biol. 2019, 72-73, 49-54.

DOI: 10.1016/j.nucmedbio.2019.07.007