Description

Other name: 3-Hydroxy-1,2:5,6-dibenzocyclooct-7-yne.

Building block for the strain-promoted copper-free click chemistry ligation techniques. Can be attached to the protein, peptide or small molecule via ether or ester bond.

Ref.:

1) The one-pot nonhydrolysis Staudinger reaction and Staudinger or SPAAC ligation.

L. Cheng, X. Kang, D. Wang, Y. Gao, L. Yi,  Z. Xi, Org. Biomol. Chem. 2019, 17, 5675-5679.

DOI: 10.1039/C9OB00528E