Description

Other names: (1α,8α,9β)-Bicyclo[6.1.0]non-4-yne-9-methanol.

Building block for the strain-promoted copper-free click chemistry ligation techniques. Can be attached to the protein, peptide or small molecule via ether or ester bond. The hydroxyl functionality can also be used as a leaving group in nucleophilic substitution reactions.

Ref.:

1) Bicyclononynes: New Ring-Strained Alkynes for Bioorthogonal Labeling.

J. Dommerholt, S. Schmidt, R. Temming, L. J. A. Hendriks, F. P. J. T. Rutjes, J. C. M. van Hest, D. J. Lefeber, P. Friedl, F. L. van Delft, Synfacts 2011, 2, 0157-0157.

DOI: 10.1055/s-0030-1259250