Description

Other name: sulfosuccinimidyl 2-((4,4′-azipentanamido)ethyl)-1,3′-dithiopropionate;

A water soluble form of SDAD-NHS ester, this crosslinker combines proven amine-reactive NHS and photoreactive diazirine, that is efficiently activated by long-wave UV (330-370 nm). A 13.5Å spacer arm contains a cleavable disulfide thus separating two functionalities upon disulfide reduction. Ideal for extracellular bioconjugations, as this product is cell impermeable.

Ref.:

1) Chemical cross-linking with a diazirine photoactivatable cross-linker investigated by MALDI- and ESI-MS/MS.

A.F. Gomes, F.C. Gozzo, J. Mass. Spectrom. 2010, 45, 892-899.

DOI: 10.1002/jms.1776