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2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

Description

Other names: Hydroxyl diazirine alkyne; 3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol.

 

With two orthogonal reactive groups, this compound is ideal for light-activated ligation to a variety of functionalities by generation of a carbene which will couple irreversibly to groups in close proximity. The alkyne function allows for copper(I)-catalyzed click reactions selectively with azide functionalities.

 

Ref.:

1) Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry.

D.J. Lapinsky, Bioorg. Med. Chem., 2012, 20, 6237-6247.

DOI: 10.1016/j.bmc.2012.09.010

 

2) Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.

A. Pahl, M. Lakemeyer, M. Vielberg, M.W. Hackl, J.Vomacka, V.S. Korotov, M.L.Stein, C.Fetzer, K. Lorenz-Baath, K. Richter, H. Waldmann, M. Groll, S.A. Sieber, Angew. Chem. Int. Ed., 2015, 54, 15892-15896.

DOI: 10.1002/anie.201507266

2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

Product parameter
Information
Molecular Formula:

C7H10N2O

Molecular Weight:
138.17
Product Number:
CM1450754412
Packing size:
any amount up to 25 g
Availability:
1-2 weeks
Purity:
>95%
CAS:
1450754-41-2

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SKU: CM1450754412 Category:

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