Description

MBS is a short, amine-to-sulfhydryl bioconjugation reagent that contains NHS-ester and maleimide in meta-positions of an aromatic ring. It provides approximately 7.3Å spacer lenght between reactive functionalities.

Can be used to link a drug to a protein or peptide.

Ref.:

1) Optimization of a Stable Linker Involved DEVD Peptide-​Doxorubicin Conjugate that is Activated upon Radiation-​Induced Caspase-​3-​Mediated Apoptosis.

S.W. Chung, J. Med. Chem. 2015, 58(16); 6435-6447.

DOI: 10.1021/acs.jmedchem.5b00420.

2) Conjugation of Peptide to Carrier Proteins via m-Maleimidobenzoyl-N-Hydroxysuccinimide Ester (MBS).

J.M. Carter, The Protein Protocols Handbook, 689-692.
DOI: 10.1007/978-1-60327-259-9_118.