Description
Spirocyclic Compounds
This fragment has found application in the synthesis of PAD-4 (Protein Arginine Deiminase 4) inhibitors.
Similar to cubane, Bicyclo[1.1.1]pentane motif finds application as a phenyl-ring isostere.
J. Med. Chem., 2012, 55(7), 3414-3424
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