Pegylation Reagents – ChemiMart

Biotin-PEG-COOH

mzaug — Wed, 09 Dec 2020 15:37:54 +0000

Other names: Biotin-PEG6-COOH. Biotin-PEG6-CO₂H. Biotin-PEG6-carboxylic acid. 21-[D-(+)-Biotinylamino]-4,7,10,13,16,19-hexaoxaheneicosanoic acid.

Biotin-PEG-linker with end-carboxylic acid functionalty that is suitable for coupling to variuous amine functionalities, e.g. proteins, peptides or API molecules bearing free amino group.

The biotin motif is a popular linker used in biotechnology to conjugate proteins for biochemical assays. Both streptavidin and avidin bind with biotin with high affinity and specificity, thus allowing target fishing in biological objects.

Ref.:

1) Biotin-conjugated PEGylated porphyrin self-assembled nanoparticles co-targeting mitochondria and lysosomes for advanced chemo-photodynamic combination therapy.

B. Purushothaman, J. Choi, S. Park, J. Lee, A.A. Suganya Samson, S. Honga, J.M. Song, J. Mater. Chem. B 2019, 7, 65-79.

Azido-PEG7

mzaug — Wed, 09 Dec 2020 15:35:58 +0000

Other names: O-(2-Azidoethyl)heptaethylene glycol.

Azid-terminated bifunctional pegylation reagent with monodisperse linker of the defined length. Suitable for click-chemistry and Staudinger ligation. Attachment to various moleculs is possible at the hydroxyl function via ester or ether bonds.

Mal-PEG-NHS

mzaug — Wed, 09 Dec 2020 15:34:02 +0000

Other names: Maleimidopropionyl-PEG NHS ester. O-[N-(3-Maleimidopropionyl)-aminoethyl]-O′-[3-(N-succinimidyloxy)-3-oxopropyl]heptacosaethylene glycol.

Doubly functionalized pegylation reagent with a monodisperse linker of the defined lenght. Can be used for the pegylation of proteins, peptides and other biomacromolecules and subsequent attachment of the so produced conjugates to nanoparticles or trasfection transport systems.

MeO-PEG-Mal

mzaug — Wed, 09 Dec 2020 15:31:16 +0000

Other names: Methoxypolyethylene glycol maleimide. PEG-maleimide. Mono-Methyl polyethylene glycol 2-maleimidoethyl ether.

Methoxypolyethyleneglycol terminated with maleimide functionality.

Can be used for the pegylation of the proteins and small peptides via Michael addition of the thiol residues of cysteins.

Enhances water solubility and conformational stability to proteins and other biomolecules.

Biotin-PEG-Amine

mzaug — Wed, 09 Dec 2020 15:28:14 +0000

Other names: O-(2-Aminoethyl)-O′-[2-(biotinylamino)ethyl]octaethylene glycol. Biotin-PEG8-Amine. Biotin-PEG amine (n=8).

Doubly functionalized pegylation reagent with a monodisperse linker of the defined lenght terminated with amine functionality.

Can be used for the pegylation of proteins, peptides and other small and biomacromolecules and subsequent attachment of the produced conjugates to nanoparticles or trasfection transport systems.

Ref.:

1) Coupling of Biotin−(poly(ethylene glycol))amine to Poly(d,l-lactide-co-glycolide) Nanoparticles for Versatile Surface Modification.

B. Weiss, M. Schneider, L. Muys, S. Taetz, D. Neumann, U. F. Schaefer, C.-M. Lehr, Bioconjugate Chem. 2007, 18, 1087-1094.

DOI: 10.1021/bc060342f